| 名称 |
胃泌素 - 17(Gastrin-17, G-17) |
| 来源物种 |
最初发现于猫(Felis silvestris catus) |
| 记录时间 |
2025/2/11 17:24:19 |
| 氨基酸个数 |
16 |
| 单字母序列 |
Pyr-GPWLEEEEAAYGWMDF-NH₂ |
| 三字母序列 |
Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Ala-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂ |
| 分子式 |
C₉₅H₁₂₂N₂₀O₂₉S₁ |
| 平均分子量 |
2040.17 |
| 精确分子量 |
2038.84 |
| 等电点(pI) |
3.46 |
| pH=7.0 时的净电荷数 |
-4 |
| GRAVY 值 |
-0.66 |
| 亲水残基比例 |
0.06 |
| 消光系数 |
12490 |
| 溶解建议 |
疏水 |
| 核心特性 |
与胃酸分泌存在负反馈调节机制;被认为与胃食管反流病(GERD)的发生发展相关 |
| 英文描述 |
This Gastrin-17 was originally found in cat (Felis silvestris catus). Gastrin 17 (G-17) has been proposed to be related with GERD(gastroesophageal reflux disease), due to the negative feedback between acid secretion and this peptide. |
| 参考文献 |
Reeve JR Jr, Dimaline R, Shively JE, Hawke D, Chew P, Walsh JH. Unique amino terminal structure of rat little gastrin. Peptides. 1981 Winter;2(4):453-8. doi: 10.1016/s0196-9781(81)80104-0. PMID: 7329823 |
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