TD-HF813010

Iv0049 is a humanized monoclonal antibody that targets and neutralizes interferon-gamma (IFN-γ), a cytokine associated with inflammatory pathways. It has been investigated for potential use in autoimmune diseases such as Crohn’s disease. By binding IFN-γ, Iv0049 reduces downstream inflammatory signaling and its detrimental effects on intestinal barrier integrity. Early clinical studies have reported signs of therapeutic activity and generally manageable tolerability, although some serious adverse events, including disease exacerbation, were observed. Iv0049 has not been described as a currently marketed therapy, and its broader clinical development status remains unclear.

Human

ELISA, Neutralization, FCM

Human

IgG1

Iv0049

Monoclonal

Interferon gamma, IFN-gamma, Immune interferon, IFNG, IFN-γ

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P01579

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

SEC-HPLC detection for InVivoMAb Anti-Human IFNG/IFN-gamma (ABV0012).　　|　　SDS-PAGE for InVivoMAb Anti-Human IFNG/IFN-gamma (Iv0049).　　|　　Flow-cytometry using APC anti-human IFNG antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained intracellularly with an APC anti-human IFNG monoclonal antibody (Catalog No.:TD-HF813010) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.,Flow-cytometry using anti-human IFNG antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained intracellularly with an anti-human IFNG monoclonal antibody (Catalog No.:TD-HF813010) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (Catalog No.:TD-HF690414) and cells analysed on a NovoCyte Flow Cytometer.

For research use only. Not suitable for clinical or therapeutic use.