抗体
试剂盒
多肽
蛋白
组织芯片
产品中心
Product Center
Research Grade Cetrelimab
All
TD-HS870046_1.jpg
TD-HS870046_2.jpg
TD-HS870046_3.jpg
- Catalog： TD-HS870046
- Clonality： mAb
- Application： Research Grade Biosimilar
- Synonyms： JNJ-63723283,CAS:2050478-92-5
-
规格：
1mg
-
价格：
¥询价
定制服务咨询
Research Grade Cetrelimab
| Catalog No. | TD-HS870046 |
|---|---|
| Species reactivity | Human |
| Applications | Research Grade Biosimilar |
| Host species | Human |
| Isotype | IgG4-kappa |
| Expression system | Mammalian Cells |
| Clonality | Monoclonal |
| Target | Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279 |
| Endotoxin level | Please contact the lab for this information. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Purification | Protein A/G, purified from cell culture supernatant. |
| Accession | Q15116 |
| Form | Liquid |
| Storage buffer | 0.01M PBS,pH7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | JNJ-63723283,CAS:2050478-92-5 |
| Background | Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo. |
| Note | For research use only. Not for use in clinical or therapeutic applications. |
|
|
SEC-HPLC detection for Research Grade Cetrelimab. |
|
|
Detects Human CD279/PDCD1/PD1 in indirect ELISAs. |
|
|
SDS-PAGE for Research Grade Cetrelimab. |