TD-HV066016

Latozinemab(TD-HV066016) is a research-grade recombinant antibody targetingNeurotensin receptor 3. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1-Kappa

Monoclonal

Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q99523

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

AL001, 2376132-27-1

Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research.• The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor., PMID:9756851• Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice., PMID:39170542• Neurotrophins and their involvement in digestive cancers., PMID:30741921• Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury., PMID:35634462• Peptides other than the neurotrophins that can be cleaved from proneurotrophins: a neglected story., PMID:17917853• The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid., PMID:34360553• Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons., PMID:21261755• Neurotrophins and their receptors in early development of the mammalian nervous system., PMID:21196952• Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing., PMID:19940174

SDS-PAGE for Research Grade Latozinemab

For research use only. Not suitable for clinical or therapeutic use.