TD-HV162016

Vantictumab(TD-HV162016) is a research-grade recombinant antibody targetingFzE1. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG2-lambda

Monoclonal

FzE1, Frizzled-1, hFz1, Fz-1, FZD1

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q9UP38

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

OMP-18R5, 1345009-45-1

Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma.• Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation., PMID:29482174• The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway., PMID:14739301• Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway., PMID:22484497• Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry., PMID:20051274• Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?, PMID:18715140• Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1., PMID:27695039• Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response., PMID:10557084• Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation., PMID:34390652• miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1., PMID:27643554• FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells., PMID:24814288

SDS-PAGE for Research Grade Vantictumab.　　|　SEC-HPLC detection for Research Grade Vantictumab.　　|　Western blot analysis was performed using anti-FZD7 monoclonal antibody at 1ug/mL on various samples.Lane 1:recombinant human FZD7 (Catalog No:TD-HF587011)Lane 2:negative control

For research use only. Not suitable for clinical or therapeutic use.