TD-HV166066

Iluzanebart(TD-HV166066) is a research-grade recombinant antibody targetingTriggering receptor expressed on myeloid cells 2. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1-kappa

Monoclonal

Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q9NZC2

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

2733621-19-5

Iluzanebart is a human IgG1κ antibody targeting TREM2, a triggering receptor expressed on myeloid cells.• Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma., PMID:38237157• TREM2, microglia, and Alzheimer's disease., PMID:33516818• Distinct roles of TREM2 in central nervous system cancers and peripheral cancers., PMID:38788719• TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration., PMID:37442133• TREM2, Microglia, and Neurodegenerative Diseases., PMID:28442216• Microglia and TREM2., PMID:38821351• TREM2 dependent and independent functions of microglia in Alzheimer's disease., PMID:36564824• TREM2: A new player in the tumor microenvironment., PMID:36989543• TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis., PMID:33586673• How neuroinflammation contributes to neurodegeneration., PMID:27540165

SDS-PAGE for Research Grade Iluzanebart.

For research use only. Not suitable for clinical or therapeutic use.