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Research Grade Elezanumab
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- Catalog： TD-HV303016
- Clonality： mAb
- Application： Research Grade Biosimilar
- Synonyms： ABT-555,AE12-1Y-QL(derivedfromparentalmAbAE12-1andAE12-1Y),CAS:1791416-49-3
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规格：
1mg
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价格：
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Research Grade Elezanumab
| Catalog No. | TD-HV303016 |
|---|---|
| Species reactivity | Human |
| Applications | Research Grade Biosimilar |
| Host species | Human |
| Isotype | IgG1-lambda |
| Expression system | Mammalian Cells |
| Clonality | Monoclonal |
| Target | RGM domain family member A, RGMA, RGM, Repulsive guidance molecule A |
| Endotoxin level | Please contact the lab for this information. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Purification | Protein A/G, purified from cell culture supernatant. |
| Accession | Q96B86 |
| Form | Liquid |
| Storage buffer | 0.01M PBS,pH7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | ABT-555,AE12-1Y-QL(derivedfromparentalmAbAE12-1andAE12-1Y),CAS:1791416-49-3 |
| Background | Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism. |
| Note | For research use only. Not for use in clinical or therapeutic applications. |
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SEC-HPLC detection for Research Grade Elezanumab. |
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Detects RGMA in indirect ELISAs. |
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SDS-PAGE for Research Grade Elezanumab. |