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Research Grade Enoticumab
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TD-HV571026_1.jpg
TD-HV571026_2.jpg
- Catalog： TD-HV571026
- Clonality： mAb
- Application： Research Grade Biosimilar
- Synonyms： REGN-421,SAR153192,CAS:1192578-27-0
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规格：
1mg
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价格：
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Research Grade Enoticumab
| Catalog No. | TD-HV571026 |
|---|---|
| Species reactivity | Human |
| Applications | Research Grade Biosimilar |
| Host species | Human |
| Isotype | IgG1-kappa |
| Expression system | Mammalian Cells |
| Clonality | Monoclonal |
| Target | Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4 |
| Endotoxin level | Please contact the lab for this information. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Purification | Protein A/G, purified from cell culture supernatant. |
| Accession | Q9NR61 |
| Form | Liquid |
| Storage buffer | 0.01M PBS,pH7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | REGN-421,SAR153192,CAS:1192578-27-0 |
| Background | Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively. |
| Note | For research use only. Not for use in clinical or therapeutic applications. |
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SEC-HPLC detection for Research Grade Enoticumab. |
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Detects DLL4 in indirect ELISAs. |