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Research Grade Teprotumumab
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- Catalog： TD-HY353036
- Clonality： mAb
- Application： Research Grade Biosimilar
- Synonyms： RO4858696-000,CAS:1036734-93-6
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规格：
1mg
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价格：
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Research Grade Teprotumumab
| Catalog No. | TD-HY353036 |
|---|---|
| Species reactivity | Human |
| Applications | Research Grade Biosimilar |
| Host species | Human |
| Isotype | IgG1-nd |
| Expression system | Mammalian Cells |
| Clonality | Monoclonal |
| Target | CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor |
| Endotoxin level | Please contact the lab for this information. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Purification | Protein A/G, purified from cell culture supernatant. |
| Accession | P08069 |
| Form | Liquid |
| Storage buffer | 0.01M PBS,pH7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | RO4858696-000,CAS:1036734-93-6 |
| Background | Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research. |
| Note | For research use only. Not for use in clinical or therapeutic applications. |
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SEC-HPLC detection for Research Grade Teprotumumab. |
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Detects Human CD221/IGF1R in indirect ELISAs. |
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SDS-PAGE for Research Grade Teprotumumab. |