TD-HY550026

Burfiralimab(TD-HY550026) is a research-grade recombinant antibody targetingVimentin. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG4-kappa

Monoclonal

Vimentin, VIM

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P08670

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

hzVSF-v13, hzVSF_var13, HzVSF-13, 2460809-80-5

Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies.• Roles of vimentin in health and disease., PMID:35487686• Spatial single-cell protein landscape reveals vimentinhighmacrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma., PMID:39327501• Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin., PMID:37641404• FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression., PMID:37915048• Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier., PMID:35433510• Vimentin on the move: new developments in cell migration., PMID:30505430• Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma., PMID:38901494• Vimentin as a universal receptor for pseudorabies virus infection in pig and human cells., PMID:39549807• PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells., PMID:39294765• Vimentin, colon cancer progression and resistance to butyrate and other HDACis., PMID:27072512

SDS-PAGE for Research Grade Burfiralimab

For research use only. Not suitable for clinical or therapeutic use.