TD-HY583046

Satralizumab(TD-HY583046) is a research-grade recombinant antibody targetingCD126. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG2-kappa

Monoclonal

sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P08887

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Sapelizumab, SA-237, SA237, satralizumab-mwg, 1535963-91-7

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).• Expression of Interleukin 6 signaling receptors in carotid atherosclerosis., PMID:33350884• Preclinical development of CD126 CAR-T cells with broad antitumor activity., PMID:33414408• Physiological effects of modulating the interleukin-6 axis., PMID:29982781• Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge., PMID:33471392• IL6 receptor inhibitors: exploring the therapeutic potential across multiple diseases through drug target Mendelian randomization., PMID:39229261• Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism., PMID:34576053• Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19., PMID:35634332• M1-Like Macrophages Modulate Fibrosis and Inflammation of Orbital Fibroblasts in Graves' Orbitopathy: Potential Relevance to Soluble Interleukin-6 Receptor., PMID:36617890• The IL-6-neutralizing sIL-6R-sgp130 buffer system is disturbed in patients with type 2 diabetes., PMID:31237452• Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses., PMID:23946454

SEC-HPLC detection for Research Grade Satralizumab.　　|　Detects Human CD126/IL6R/IL-6RA in indirect ELISAs.　　|　SDS-PAGE for Research Grade Satralizumab.

For research use only. Not suitable for clinical or therapeutic use.