TD-JN822016

Setoxaximab(TD-IN822016) is a research-grade recombinant antibody targetingshiga toxin type 2stx2A. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Escherichia coli

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Chimeric

IgG1-kappa

Monoclonal

shiga toxin type 2stx2A

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P09385

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Shigamabs(drugnameforthecombinationofpritoxaximabandsetoxaximab), caStx2, 1351470-17-1

Setoxaximab is an IgG1-κ humanized chimeric antibody targeting shiga toxin type 1.• Shiga Toxin (Stx) Classification, Structure, and Function., PMID:25530917• Shiga-toxin-converting bacteriophages., PMID:11686382•Escherichia albertiiPathogenesis., PMID:32588811• Shiga Toxin-ProducingEscherichia coliInfections during Pregnancy., PMID:30360505• Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-ProducingEscherichia coli(STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice., PMID:33467588• Targeting bacterial toxins., PMID:22441768• Shiga toxin-induced haemolytic uraemic syndrome and the role of antibiotics: a global overview., PMID:31150744• L-Arabinose inhibits Shiga toxin type 2-converting bacteriophage induction inEscherichia coliO157:H7., PMID:37332116• Shiga toxin 2a and Enteroaggregative Escherichia coli--a deadly combination., PMID:26039753• Shiga Toxin (Stx) Type 1a and Stx2a Translocate through a Three-Layer Intestinal Model., PMID:36977098

SEC-HPLC detection for Research Grade Setoxaximab.　　|　SDS-PAGE for Research Grade Setoxaximab

For research use only. Not suitable for clinical or therapeutic use.