TD-AV974024

ELISA

Rabbit

IgG

Polyclonal

Avelumab

Rabbit polyclonal to Bavencio.

The product is specific for Avelumab. This antibody serves as an excellent positive control for Avelumab immunogenicity (ADA) assays.

Please contact with the lab for this information.

Purified by antigen affinity column.

CAS: 1537032-82-8

Liquid

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

ELISA　|　IHC　|　WB

1:5000-1:20000　|　1:50-1:500　|　1:500-1:2000

The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.

Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as

For research use only.