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Mouse Monoclonal Antibody to CD46
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- Catalog： TD-31495
- Clonality： mAb
- Application： FCM, IHC
- Synonyms： MCP; TLX; AHUS2; MIC10; TRA2.10
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规格：
100ul 50ul
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价格：
¥2180
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Mouse Monoclonal Antibody to CD46
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| Description | |
| The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. | |
| Specification | |
| Aliases | MCP; TLX; AHUS2; MIC10; TRA2.10 |
| Entrez GeneID | 4179 |
| Swissprot | P15529 |
| clone | 1A5A5 |
| WB Predicted band size | 43.7kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application | |
| IHC | 1/200 - 1/1000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
| Product Image | |
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| Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) | Flow cytometric analysis of K562 cells using CD46 mouse mAb (green) and negative control (red). | Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD46 mouse mAb with DAB staining. |
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| Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CD46 mouse mAb with DAB staining. |