This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
Specification
Aliases
SIGLEC5; OBBP2; CD33L2; OB-BP2; SIGLEC-5
Entrez GeneID
8778
Swissprot
O15389
clone
3F5A3
WB Predicted band size
60.7kDa
Host/Isotype
Mouse IgG2a
Antibody Type
Primary antibody
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CD170 (AA: extra 17-230) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Application
FCM
1/200 - 1/400
ELISA
1/10000
Product Image
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of HL-60 cells using CD170 mouse mAb (green) and negative control (red).