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CD186
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ELISA
WB
FCM
- Catalog： TD-32209
- Clonality： mAb
- Application： WB, FCM
- Synonyms： CXCR6; BONZO; CDw186; STRL33; TYMSTR
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规格：
100ul 50ul
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价格：
¥2180
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Mouse Monoclonal Antibody to CD186
| Description | |
| The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. |
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| Specification | |
| Aliases | CXCR6; BONZO; CDw186; STRL33; TYMSTR |
| Entrez GeneID | 10663 |
| Swissprot | O00574 |
| clone | 2A4D10 |
| WB Predicted band size | 39.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD186 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application | |
| WB | 1/500 - 1/2000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
| Product Image | |
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Western blot analysis using CD186 mouse mAb against K562 (1), Jurkat (2), and HT-29 (3) cell lysate.
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Flow cytometric analysis of Jurkat cells using CD186 mouse mAb (green) and negative control (red).
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