This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Specification
Aliases
TEK; TIE2; VMCM; GLC3E; TIE-2; VMCM1
Entrez GeneID
7010
Swissprot
Q02763
clone
3F5B9
WB Predicted band size
125.8kDa,
Host/Isotype
Mouse IgG2b
Antibody Type
Primary antibody
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CD202B (AA: extra 571-748) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Application
FCM
1/200 - 1/400
ELISA
1/10000
Product Image
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of HL-60 cells using CD202B mouse mAb (green) and negative control (red).