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CD204
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ELISA
WB
FCM
- Catalog： TD-31541
- Clonality： mAb
- Application： WB, FCM
- Synonyms： MSR1; SRA; SR-A; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
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规格：
100ul 50ul
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价格：
¥2180
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Mouse Monoclonal Antibody to CD204
| Description | |
| This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
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| Specification | |
| Aliases | MSR1; SRA; SR-A; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII |
| Entrez GeneID | 4481 |
| Swissprot | P21757 |
| clone | 5B8H4 |
| WB Predicted band size | 49.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application | |
| WB | 1/500 - 1/2000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
| Product Image | |
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Western blot analysis using CD204 mouse mAb against PC-2 (1), A549 (2), HepG2 (3), L-02 (4), and PANC-1 (5) cell lysate.
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Flow cytometric analysis of HL-60 cells using CD204 mouse mAb (green) and negative control (red).
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