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Mouse Monoclonal Antibody to CD209
All
ELISA
WB
FCM
- Catalog： TD-31356
- Clonality： mAb
- Application： WB, FCM
- Synonyms： CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
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规格：
100ul 50ul
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价格：
¥2180
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Mouse Monoclonal Antibody to CD209
| Description | |
| This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. | |
| Specification | |
| Aliases | CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1 |
| Entrez GeneID | 30835 |
| Swissprot | Q9NNX6 |
| clone | 5C2A6 |
| WB Predicted band size | 45.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD209 (AA: extra 270-404) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application | |
| WB | 1/500 - 1/2000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
| Product Image | |
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Western blot analysis using CD209 mouse mAb against Hela (1), U937 (2), THP-1 (3), HL-60 (4), and A431 (5) cell lysate.
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Flow cytometric analysis of Ramos cells using CD209 mouse mAb (green) and negative control (red).
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