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CD274
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ELISA
FCM
- Catalog： TD-31027
- Clonality： mAb
- Application： FCM
- Synonyms： B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
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规格：
100ul 50ul
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价格：
¥2180
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Mouse Monoclonal Antibody to CD274
| Description | |
| This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. | |
| Specification | |
| Aliases | B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1 |
| Entrez GeneID | 29126 |
| Swissprot | Q9NZQ7 |
| clone | 7D2A10 |
| WB Predicted band size | 33.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD274 (AA: 24-153) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application | |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
| Product Image | |
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Flow cytometric analysis of Hela cells using CD274 mouse mAb (green) and negative control (red).
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