TD-VK617020

The Iv0038 monoclonal antibody recognizes HIV-1 gp120, a heavily glycosylated ~120 kDa envelope glycoprotein that forms the outer subunit of the viral Env complex. gp120 mediates viral attachment by binding to the CD4 receptor and coreceptors such as CCR5 or CXCR4 on target cells, making it a key determinant of viral entry and tropism. By targeting conformational epitopes on gp120, Iv0038 can neutralize HIV-1, blocking the interaction between gp120 and host receptors and thereby preventing fusion and subsequent infection. Because gp120 is exposed on the virion surface and undergoes conformational changes during receptor engagement, antibodies like Iv0038 are valuable tools for studying viral entry mechanisms, Env antigenicity, and immune responses to HIV-1.

Human immunodeficiency virus 1 (HIV-1)

ELISA, Neutralization

Human

IgG1, lambda2

Iv0038

Monoclonal

Envelope glycoprotein gp160, Env polyprotein, Surface protein gp120, SU, Glycoprotein 120, gp120, Transmembrane protein gp41, TM, Glycoprotein 41, gp41, env

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q03805

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

SDS-PAGE for InVivoMAb Anti-HIV1 gp120/Glycoprotein 120 (Iv0038).

For research use only. Not suitable for clinical or therapeutic use.