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Research Grade Bimekizumab
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- Catalog： TD-HS856036
- Clonality： mAb
- Application： Research Grade Biosimilar
- Synonyms： CDP4940, UCB-4940, UCB4940, CAS: 1418205-77-2
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规格：
1mg
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价格：
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Research Grade Bimekizumab
| Catalog No. | TD-HS856036 |
|---|---|
| Species reactivity | Human |
| Applications | Research Grade Biosimilar |
| Host species | Humanized |
| Isotype | IgG1-kappa |
| Expression system | Mammalian Cells |
| Species | Human |
| Clonality | Monoclonal |
| Target | CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL-17A, IL17A, CTLA8, IL-17, Interleukin-17A, IL17F, Interleukin-17F, IL-17F, Cytokine ML-1 |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | Q16552 & Q96PD4 |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Alternate Names | CDP4940, UCB-4940, UCB4940, CAS: 1418205-77-2 |
| Background | Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation. |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
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Detects IL17F in indirect ELISAs. |
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SEC-HPLC detection for Research Grade Bimekizumab. |
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Detects Human IL17A in indirect ELISAs. |
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Flow-cytometry using anti-human IL17A&IL17F antibody. Jurkat cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an anti-human IL17A&IL17F monoclonal antibody (Catalog HS856036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer. |
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SDS-PAGE for Research Grade Bimekizumab. |