Mouse Monoclonal Antibody to CD59-武汉天德生物科技有限公司

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Mouse Monoclonal Antibody to CD59

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Catalog： TD-30428
Clonality： mAb
Application： FCM, IHC, IF
Synonyms： 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
规格：
100ul 50ul
价格：
¥2180

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Mouse Monoclonal Antibody to CD59
Description
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Specification
Aliases	1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
Entrez GeneID	966
Swissprot	P13987
clone	8D2B8
WB Predicted band size	14.2kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide
Application
IHC	1/200 - 1/1000
ICC	1/50 - 1/200
FCM	1/200 - 1/400
ELISA	1/10000
Product Image


Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);	Immunofluorescence analysis of MCF-7 cells using CD59 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.	Immunofluorescence analysis of Hela cells using CD59 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of HeLa cells using CD59 mouse mAb (green) and negative control (red).	Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CD59 mouse mAb with DAB staining.	Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using CD59 mouse mAb with DAB staining.