The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
Specification
Aliases
THBD; TM; THRM; AHUS6; BDCA3; THPH12
Entrez GeneID
7056
Swissprot
P07204
clone
2C6C3
WB Predicted band size
60.3kDa
Host/Isotype
Mouse IgG1
Antibody Type
Primary antibody
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CD141 (AA: extra 297-505) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Application
FCM
1/200 - 1/400
ELISA
1/10000
Product Image
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of HL-60 cells using CD141 mouse mAb (green) and negative control (red).